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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
Cayman’s 15-PGDH Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human 15-PGDH, the enzyme that catalyzes the oxidation of prostaglandins to 15-keto metabolites with reduced biological activity. Measurement of 15-PGDH activity is carried out by monitoring the reduction of NAD+ to NADH. The reduction of NAD+ to NADH is accompanied by an increase in fluorescence at 445 nm following excitation at 340 nm. The potent and reversible 15-PGDH inhibitor ML-148 Assay Reagent is included as a positive control and inhibits 15-PGDH with an IC50 value of 11 nM.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Nutlin-3a is a small-molecule MDM2 antagonist used in research to activate wild-type p53, stabilize p53 protein, and induce apoptosis and autophagy. It is intended for laboratory research use and is characterized for cell-based and biochemical assays.
Inhibits MDM2-p53 interaction, leading to p53 activation.
Induces apoptosis and autophagy in p53 wild-type cells.
High reported purity (≈99.1%) suitable for research applications.
Molecular formula C30H30Cl2N4O4 and molecular weight ~581.5 g/mol.
Available in multiple solid and solution sizes for experimental flexibility.
For research use only; not for human or animal therapeutic use.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Recombinant mouse myelin-associated glycoprotein (MAG/Siglec-4a) produced in HEK293 cells and supplied as a lyophilized, C-terminal 6xHis-tagged protein for biochemical and cell-based assays. Formulated from HEPES or phosphate buffer, the product has a reported molecular weight of 70-120 kDa and demonstrated activity in SH-SY5Y inhibition assays. Store frozen and aliquot to prevent repeated freeze-thaw.
Recombinant mouse MAG/Siglec-4a for functional assays.
Expressed in HEK293 to preserve mammalian post-translational modifications.
C-terminal 6xHis tag for purification and detection.
Lyophilized from buffered saline for stability and transport.
Reported molecular weight 70-120 kDa.
Demonstrated biological activity (ED50 ~3.13 μg/mL in SH-SY5Y assays).
Store at -20°C and aliquot to minimize freeze-thaw cycles.
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SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serine/threonine- or tyrosine-kinases
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More